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Uridine 5′-diphosphoglucose disodium salt

Name: Uridine 5′-diphosphoglucose disodium salt
Brand: TargetMol
SKU: T4743
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Uridine 5'-diphosphoglucose disodium sal, UDP-α-D-Glucose sodium salt, UDP-Glucose sodium salt, UDPG sodium salt) Copy Product Info

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Synonyms: Uridine 5'-diphosphoglucose disodium sal, UDP-α-D-Glucose sodium salt, UDP-Glucose sodium salt, UDPG sodium salt

Catalog No. T4743 Copy Product Info

Purity: 99.83%

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Uridine 5′-diphosphoglucose disodium salt (UDP-glucose) is a natural product and a P2Y14 receptor agonist (EC50 = 0.35 μM) with endogenous activity and selectivity. It is used for studying mechanisms related to cardiac inflammation following myocardial infarction/reperfusion injury.

Cas No. 28053-08-9

Pack Size	Price	USA Stock	Global Stock	Quantity
100 mg	$42	In Stock	In Stock
500 mg	$95	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.83%

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Uridine 5′-diphosphoglucose disodium salt (UDP-glucose) is a natural product and a P2Y14 receptor agonist (EC50 = 0.35 μM) with endogenous activity and selectivity. It is used for studying mechanisms related to cardiac inflammation following myocardial infarction/reperfusion injury.
Targets & IC50	P2Y14 receptor:0.35 μM (EC50)
In vitro	Methods: Neutrophils were treated with Uridine 5′-diphosphoglucose disodium salt (0-100 μM) for 24 hours. P2Y14 receptor expression and cell apoptosis were detected. Results: Uridine 5′-diphosphoglucose disodium salt upregulated P2Y14 receptor expression and induced neutrophil apoptosis. [1] Methods: Mouse neutrophils were incubated with PPTN alone or combined with UDP-Glu (1 μM) for 24 hours. Cell viability was detected by CCK-8 assay, apoptosis and polarization (N1/N2) were detected by flow cytometry, migration ability was detected by Transwell, and P2Y14 expression was detected by Western Blot. Results: PPTN significantly reversed UDP-Glu-induced decreased cell viability, increased apoptosis, and inhibited migration, promoted N2 polarization, and reduced inflammatory factor expression. [2]
Synonyms	Uridine 5'-diphosphoglucose disodium sal, UDP-α-D-Glucose sodium salt, UDP-Glucose sodium salt, UDPG sodium salt

Chemical Properties

Molecular Weight	610.27
Formula	C₁₅H₂₂N₂Na₂O₁₇P₂
Cas No.	28053-08-9
Smiles	[Na+].[Na+].OC[C@@H](OP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O)OP([O-])([O-])=O)[C@@H](O)[C@H](O)[C@@H](O)C=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Store under nitrogen,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 125 mg/mL (204.83 mM), Sonication is recommended.

DMSO: 128.75 mg/mL (210.97 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (8.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6386 mL	8.1931 mL	16.3862 mL	81.9309 mL
5 mM	0.3277 mL	1.6386 mL	3.2772 mL	16.3862 mL
10 mM	0.1639 mL	0.8193 mL	1.6386 mL	8.1931 mL
20 mM	0.0819 mL	0.4097 mL	0.8193 mL	4.0965 mL
50 mM	0.0328 mL	0.1639 mL	0.3277 mL	1.6386 mL
100 mM	0.0164 mL	0.0819 mL	0.1639 mL	0.8193 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

Uridine 5′diphosphoglucose disodium saltUridine 5′-diphosphoglucose disodiumUridine 5′-diphosphoglucoseUridine 5′ diphosphoglucose disodium saltUDP-α-D-Glucose sodiumUDP-Glucose sodiumUDPG sodiumUDP-alpha-D-Glucose sodiumUDP-a-D-Glucose sodiumP2YReceptorP2Y14P2Y ReceptorP2YInhibitorinhibitEndogenousMetaboliteEndogenous Metabolite

Related Tags: Uridine 5′-diphosphoglucose disodium salt chemical structure | Uridine 5′-diphosphoglucose disodium salt in vitro | Uridine 5′-diphosphoglucose disodium salt formula | Uridine 5′-diphosphoglucose disodium salt molecular weight